Background:

FEV (FEV, ETS transcription factor) belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. FEV is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, FEV is fused to the Ewing sarcoma (EWS) gene following chromosome translocations.

Classification:

Primary antibody

Alternative names:

FEV; PET1; Protein FEV; Fifth Ewing variant protein; PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; Pet-1

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the N-terminal region of human FEV.

Concentration:

1 mg/ml

Molecular weight:

25030

Applications:

WB, ELISA

Storage:

-20°C for one year

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