Background:

RIMKLA (N-acetylaspartyl-glutamate synthetase A) is a 391 amino acid protein that belongs to the rimK family. Localizing to cytoplasm, RIMKLA contains one ATP-grasp domain and binds two manganese ions per subunit. RIMKLA catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG). RIMKLA, is almost exclusively expressed in the CNS, whereas RIMKLB, which shares 65% sequence identity with RIMKLA, is expressed in CNS and testis. It has also been suggested that RIMKLA and RIMKLB also served to ligate free glutamate to (an) acceptor (s). RIMKLA catalyzed the ATP-dependent synthesis of N-acetylaspartylglutamate (NAAG) from N-acetylaspartate and L-glutamate. RIMKLB catalyzed this reaction as well as the synthesis of β-citrylglutamate. The RIMKLA gene is conserved in chimpanzee, dog, cow and mouse, and maps to human chromosome 1p34.2.

Classification:

Primary antibody

Alternative names:

RIMKLA; FAM80A; N-acetylaspartyl-glutamate synthetase A; NAAG synthetase A; NAAGS; Ribosomal protein S6 modification-like protein A

Species reactivity:

Human;Mouse;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human RIMKA. AA range:112-161

Concentration:

1 mg/ml

Molecular weight:

42864

Applications:

WB, ELISA

Storage:

-20°C for one year

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