Background:

FAM111B encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin-like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.

Classification:

Primary antibody

Alternative names:

FAM111B; CANP; Protein FAM111B; Cancer-associated nucleoprotein

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human F111B. AA range:281-330

Concentration:

1 mg/ml

Molecular weight:

84674

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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