Background:

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. GFM2 (G elongation factor mitochondrial 2) encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Classification:

Primary antibody

Alternative names:

GFM2; EFG2; MSTP027; Ribosome-releasing factor 2; mitochondrial; RRF2mt; Elongation factor G 2, mitochondrial; EF-G2mt; mEF-G 2; Elongation factor G2; hEFG2

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human GFM2. AA range:441-490

Concentration:

1 mg/ml

Molecular weight:

86601

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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