Background:

Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.

Classification:

Primary antibody

Alternative names:

DTYMK; CDC8; TMPK; TYMK; Thymidylate kinase; dTMP kinase

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human DTYMK. AA range:1-50

Concentration:

1 mg/ml

Molecular weight:

23819

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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