Background:

The docking protein 7 encoded by DOK7 is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in DOK7 are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

DOK7; C4orf25; Protein Dok-7; Downstream of tyrosine kinase 7

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human DOK7. AA range:10-59

Concentration:

1 mg/ml

Molecular weight:

53097

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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