Background:

Dedicator of cytokinesis protein 2 encoded by DOCK2 belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection.

Classification:

Primary antibody

Alternative names:

DOCK2; KIAA0209; Dedicator of cytokinesis protein 2

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from the Internal region of human DOCK 2.

Concentration:

1 mg/ml

Molecular weight:

211948

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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