Background:

DMGDH encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme (dimethylglycine dehydrogenase) is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

DMGDH; Dimethylglycine dehydrogenase; mitochondrial; ME2GLYDH

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human DMGDH. AA range:817-866

Concentration:

1 mg/ml

Molecular weight:

96807

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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