Background:

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. DEFA4 differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. Neutrophil defensin 4 encoded by DEFA4, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.

Classification:

Primary antibody

Alternative names:

DEFA4; DEF4; Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Defensin alpha4. AA range:27-76

Concentration:

1 mg/ml

Molecular weight:

10504

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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