Background:

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Neutrophil defensin 1 encoded by DEFA1, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Classification:

Primary antibody

Alternative names:

DEFA1; DEF1; DEFA2; MRS; DEFA1B; Neutrophil defensin 1; Defensin; alpha 1; HNP-1; HP-1; HP1

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Defensin alpha1. AA range:3-52

Concentration:

1 mg/ml

Molecular weight:

10201

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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