Background:

TNF receptor superfamily member 10c encoded by TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Classification:

Primary antibody

Alternative names:

TNFRSF10C; DCR1; LIT; TRAILR3; TRID; Tumor necrosis factor receptor superfamily member 10C; Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domainDecoy receptor 1; DcR1;

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from the Internal region of human TNFRSF10C. AA range:11-60

Concentration:

1 mg/ml

Molecular weight:

27395

Applications:

WB, ELISA

Storage:

-20°C for one year

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