Background:

The protein encoded by CCND3 (cyclin D3) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for CCND3.

Classification:

Primary antibody

Alternative names:

CCND3; G1/S-specific cyclin-D3

Species reactivity:

Human;Mouse;Rat;Monkey

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Cyclin D3. AA range:243-292

Concentration:

1 mg/ml

Molecular weight:

32520

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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