Background:

Cortactin, encoded by CTTN gene (formerly EMS1), was originally identified as a substrate of the Src kinase. It is a cytoskeletal protein that interacts with F-actin and Arp2/3 complex and plays an important role in regulation of actin assembly and cytoskeleton dynamics. Overexpression of cortactin increases cell migration, and is thought to contribute to the invasive phennotype of breast cancer and several other tumors. Three isoforms of cortactin exist due to the alternative splicing.

Classification:

Primary antibody

Alternative names:

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Cortactin. AA range:388-437

Concentration:

1 mg/ml

Molecular weight:

61636

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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