Background:

CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. Cortactin is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. The aberrant regulation of CTTN contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for CTTN.

Classification:

Primary antibody

Alternative names:

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized acetyl-peptide derived from the Internal region of human Cortactin around the acetylation site of K235.

Concentration:

1 mg/ml

Molecular weight:

61636

Applications:

WB, ELISA

Storage:

-20°C for one year

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