Background:

COL25A1 (collagen type XXV alpha 1 chain) encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for COL25A1.

Classification:

Primary antibody

Alternative names:

COL25A1; Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150

Concentration:

1 mg/ml

Molecular weight:

64771

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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