Background:

CCR4-NOT transcription complex subunit 7 encoded by CNOT7 binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of CNOT7 results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X.

Classification:

Primary antibody

Alternative names:

CNOT7; CAF1; CCR4-NOT transcription complex subunit 7; BTG1-binding factor 1; CCR4-associated factor 1; CAF-1

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59

Concentration:

1 mg/ml

Molecular weight:

32745

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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