Background:

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

F2; Prothrombin; Coagulation factor II

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human THRB. AA range:278-327

Concentration:

1 mg/ml

Molecular weight:

70037

Applications:

WB, ELISA

Storage:

-20°C for one year

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