Background:

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. Spectrin alpha chain non-erythrocytic 1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in SPTAN1 are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Classification:

Primary antibody

Alternative names:

SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185

Concentration:

1 mg/ml

Molecular weight:

284539

Applications:

WB, ELISA

Storage:

-20°C for one year

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