Background:

The protein encoded by CTSL is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein (cathepsin L) has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. cathepsin L, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for CTSL.

Classification:

Primary antibody

Alternative names:

CTSL1; CTSL; Cathepsin L1; Major excreted protein; MEP

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CATL1. AA range:239-288

Concentration:

1 mg/ml

Molecular weight:

37564

Applications:

WB, ELISA

Storage:

-20°C for one year

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