Background:

CTSC encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. Cathepsin Crequires chloride ions for activity and can degrade glucagon. Defects in the cathepsin C have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.

Classification:

Primary antibody

Alternative names:

CTSC; CPPI; Dipeptidyl peptidase 1; Cathepsin C; Cathepsin J; Dipeptidyl peptidase I; DPP-I; DPPI; Dipeptidyl transferase

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Dipeptidyl-peptidase 1. AA range:345-394

Concentration:

1 mg/ml

Molecular weight:

51842

Applications:

WB, ELISA

Storage:

-20°C for one year

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