Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN6 encodes a component of tight junction strands, which is a member of the claudin family. Claudin 6 is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Classification:

Primary antibody

Alternative names:

CLDN6; Claudin-6; Skullin

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CLDN6. AA range:81-130

Concentration:

1 mg/ml

Molecular weight:

23292

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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