Background:

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Classification:

Primary antibody

Alternative names:

CENPA; Histone H3-like centromeric protein A; Centromere autoantigen A; Centromere protein A; CENP-A

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CENPA. AA range:11-60

Concentration:

1 mg/ml

Molecular weight:

15991

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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