Background:

The protein encoded by CD44 (CD44 molecule (Indian blood group)) is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for CD44 undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.

Classification:

Primary antibody

Alternative names:

CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor)

Species reactivity:

Human; Mouse; Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

Synthesized peptide derived from human CD44

Concentration:

1 mg/ml

Molecular weight:

81554

Applications:

IHC-p, WB

Storage:

-20°C for one year

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