Background:

CASP10 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in CASP10 are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for CASP10.

Classification:

Primary antibody

Alternative names:

ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human Caspase 10. AA range:430-479

Concentration:

1 mg/ml

Molecular weight:

58994

Applications:

WB, IHC-p, IF, ELISA

Storage:

-20°C for one year

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