Background:

The sedoheptulokinase encoded by SHPK has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.

Classification:

Primary antibody

Alternative names:

SHPK; CARKL; Sedoheptulokinase; SHK; Carbohydrate kinase-like protein

Species reactivity:

Human;Mouse;Rat

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human CARKL. AA range:31-80

Concentration:

1 mg/ml

Molecular weight:

51504

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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