Background:

BTBD6 (BTB/POZ domain-containing protein 6), also known as BDPL or lens BTB domain protein, is a 410 amino acid protein that contains one BTB/POZ domain and is specifically expressed in the lens. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD6 may play a role in transcription regulation in the lens.

Classification:

Primary antibody

Alternative names:

BTBD6; BDPL; BTB/POZ domain-containing protein 6; Lens BTB domain protein

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human BTBD6. AA range:91-140

Concentration:

1 mg/ml

Molecular weight:

45925

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

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