Background:

BMP8B (bone morphogenetic protein 8b) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of BMP8B may be downregulated in pancreatic cancer. BMP8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.

Classification:

Primary antibody

Alternative names:

BMP8B; BMP8; Bone morphogenetic protein 8B; BMP-8; BMP-8B; Osteogenic protein 2; OP-2; BMP8A; Bone morphogenetic protein 8A; BMP-8A

Species reactivity:

Human

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human BMP-8. AA range:41-90

Concentration:

1 mg/ml

Molecular weight:

44768

Applications:

IHC-p, ELISA

Storage:

-20°C for one year

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