Background:

BMP5 encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Polymorphisms in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. BMP5 encodes distinct protein isoforms that may be similarly proteolytically processed.

Classification:

Primary antibody

Alternative names:

BMP5; Bone morphogenetic protein 5; BMP-5

Species reactivity:

Human;Mouse

Host:

Rabbit

Isotype:

IgG

Immunogen:

The antiserum was produced against synthesized peptide derived from human BMP-5. AA range:114-163

Concentration:

1 mg/ml

Molecular weight:

51737

Applications:

WB, IHC-p, ELISA

Storage:

-20°C for one year

More info:

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