Bioworld Technology

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Na+ CP type IXα polyclonal antibody BS5813

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Specifications

size	50ul/100ul

Background:

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarizes the cell. Na+ CP type IXα, also known as SCN9A (sodium channel protein type 9 subunit α), NENA, PN1, Nav1.7 or ETHA, is a 1,988 amino acid multi-pass membrane protein that belongs to the voltage-gated sodium channel family. Expressed in dorsal root ganglion, smooth muscle cells and in the central and peripheral nervous system, Na+ CP type IXα functions to mediate the voltage-dependent sodium ion permeability of membranes, specifically forming a sodium-selective ion channel through which sodium may pass. Via its ability to control the flow of sodium in and out of excitable membranes, Na+ CP type IXα plays an important role in the inflammatory pain response. Defects in the gene encoding Na+ CP type IXα are the cause of primary erythermalgia, autosomal recessive congenital indifference to pain and paroxysmal extreme pain disorder (PEPD), all of which are genetic pain disorders.

Specificity:

Na+ CP type IXα polyclonal antibody detects endogenous levels of Na+ CP type IXα protein.

Alternative names:

Sodium channel protein type 9 subunit alpha; Neuroendocrine sodium channel; hNE-Na; Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7; SCN9A; NENA

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 702-747 of Human Na+ CP type IXα.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 226 kDa

Applications:

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com