Background:

Kallmann (KAL1) syndrome is an X-linked condition characterized by hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency, and a defective sense of smell, known as anosmia, due to the underdevelopment of the olfactory bulbs. GnRH is a key regulator of reproduction and sexual behavior. Anosmia associated with Kallmann syndrome is due to a defect in the migration and targeting of GnRH-secreting neurons and olfactory axons during embryonic development. Mutations in the KAL1 gene are responsible for X-linked Kallmann syndrome. The human KAL1 gene, located in the Xp22.3 region, encodes a 680 amino acid extracellular matrix adhesion protein, known as anosmin-1. Anosmin-1 plays an essential role in the patterning of mitral and tufted cell axon collaterals to the olfactory cortex. Anosmin-1 can be detected in the basement membranes and/or interstitial matrices of various structures including bronchial tubes, muscular walls of the digestive tract and forebrain subregions.

Specificity:

KAL1 polyclonal antibody detects endogenous levels of KAL1 protein.

Alternative names:

Anosmin1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein; KAL1; ADMLX; KAL; KALIG1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 205-250 of Human KAL1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 76 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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