Background:

Cysteine-rich proteins (CRPs) participate in the organization of multiprotein complexes, both in the cytoplasm, where they participate in cytoskeletal remodeling, and in the nucleus, where they facilitate smooth muscle differentiation. CRP1 (cysteine and glycine-rich protein 1), also known as CRP, CSRP1 or CYRP, is abundant in the prostate and smooth muscle lineages. It contains two LIM zinc-binding domains and is localized in the nucleus. The LIM domains of CRP1 are critical for binding to the adhesion-plaque protein Zyxin. CRP1 also interacts with a-actinin to mediate muscle differentiation. These associations indicate that the main function of CRP1 may be structural.

Specificity:

CSRP1 polyclonal antibody detects endogenous levels of CSRP1 protein.

Alternative names:

Cysteine and glycine-rich protein 1; Cysteine-rich protein 1; CRP; CRP1; Epididymis luminal protein 141; HEL-141; HEL141; CSRP; CYRP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 88-133 of Human CSRP1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 23 kDa

Applications:

WB IHC ICC IP

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200 IP: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com