Background:

RRS1, also known as KIAA0112, ribosome biogenesis regulatory protein homolog, regulator of ribosome synthesis 1, ribosome biogenesis regulatory protein RRS1 homolog or RRR, is a 365 amino acid protein belonging to the RRS1 family. RRS1 shows nucleolar localization and is involved in both ribosome biogenesis and chromosome congression. Recent studies indicate that in the absence of RRS1, cells experience mitotic delay due to abnormal spindle organization and chromosome alignment. The gene encoding RRS1 maps to human chromosome 8q13.1. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

Specificity:

RRS1 (R286) polyclonal antibody detects endogenous levels of RRS1 protein.

Alternative names:

Homolog of yeast ribosome biogenesis regulator; Homolog of yeast ribosome biogenesis regulatory protein RRS1; KIAA0112; OTTHUMP00000227420; Ribosome biogenesis regulatory protein homolog; Ribosome biogenesis regulatory protein RRS1 homolog; RRR; rrs1;

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 255-307 of Human RRS1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 45 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com