Background:

Amyloid β precursor protein (β APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The amyloid β precursor is known to interact with several proteins, including the G heterotrimetric protein, APP-BP1, and X11. The neuronal, transmembrane protein X11 is known to bind to the amyloid β precurser protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β APP and slowing β APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β APP. Multiple splice varitents of X11 have been identified, including X11 α, β and γ (also known as Mint 1, 2 and 3, respectively).

Specificity:

X11γ (R401) polyclonal antibody detects endogenous levels of X11γ protein.

Alternative names:

Amyloid beta A4 precursor protein-binding family A member 3; Adapter protein X11gamma; Neuron-specific X11L2 protein; Neuronal Munc18-1-interacting protein 3; Mint-3; APBA3; MINT3; X11L2

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 371-420 of Human X11γ.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 61 kDa

Applications:

IHC

Usage:

IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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