Background:

MaxiK channels are large conductance voltage and Ca 2+-activated potassium channels which are formed by tetramers of MaxiKα subunits, which create pores that are used for smooth muscle tone and neuronal excitability. These MaxiKα subunits have the ability to coassemble with MaxiKβ subunits that are structurally related and are able to regulate the function of MaxiKα subunits. KCNMB4 (potassium large conductance calcium-activated channel, subfamily M, β member 4), also known as Slo-β-4 or Maxi K channel subunit β-4, is a 210 amino acid multi-pass membrane protein belonging to the KCNMB family. Predominantly expressed in brain, KCNMB4 is a regulatory subunit of the calcium activated potassium MaxiKα channel. KCNMB4 contributes to MaxiKα channel diversity by modulating calcium sensitivity and gating kinetics of MaxiKα.

Specificity:

MaxiKβ (K119) polyclonal antibody detects endogenous levels of MaxiKβ protein.

Alternative names:

Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Hbeta4; Calcium-activated potassium channel; subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel subunit beta-4; Slo-beta-4; KCNMB4

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 86-140 of Human MaxiKβ.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 24 kDa

Applications:

IHC

Usage:

IHC:1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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