Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC9 (zinc finger, DHHC-type containing 9), also known as DHHC9, CGI-89, ZNF379 or CXorf11, is a 364 amino acid protein that localizes to the membrane of the endoplasmic reticulum and contains one DHHC-type zinc finger. Expressed at high levels in brain, lung, kidney, liver and skeletal muscle, ZDHHC9 exists in a complex with GOLGA7 and, via its DHHC domain, functions as a palmitoyltransferase that is specific for H-Ras and N-Ras. Mutations in the gene encoding ZDHHC9 are associated with X-linked mental retardation and colorectal cancer, the latter of which suggests a role in tumorigenesis.

Specificity:

ZDHHC9 (K364) polyclonal antibody detects endogenous levels of ZDHHC9 protein.

Alternative names:

Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9; DHHC-9; DHHC9; Zinc finger protein 379; Zinc finger protein 380; ZDHHC9; CXorf11; ZDHHC10; ZNF379; ZNF380; CGI-89; UNQ261/PRO298

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 332-380 of Human ZDHHC9.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 41 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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