Background:

Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRphospho-L39 (mitochondrial ribosomal protein L39), also known as MRphospho-L5, L39mt or L5mt, is a 338 amino acid mitochondrial protein that exists as a component of the 39S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. MRphospho-L39 exists as two isoforms produced by alternative splicing. Isoform one of MRphospho-L39 is ubiquitously expressed while isoform two is specifically expressed in heart. The gene encoding MRphospho-L39 maps to chromosome 21, which makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer’s disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21.

Specificity:

MRphospho-L39 (E326) polyclonal antibody detects endogenous levels of MRphospho-L39 protein.

Alternative names:

39S ribosomal protein L39, mitochondrial; L39mt; MRphospho-L39; 39S ribosomal protein L5, mitochondrial; L5mt; MRphospho-L5; Mitochondrial large ribosomal subunit protein mL39; MRPL39; C21orf92; MRPL5; RPML5; MSTP003; PRED22

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 296-356 of Human MRphospho-L39.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 38 kDa

Applications:

WB

Usage:

WB: 1:1000~1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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