Background:

Synphilin-1 (α-synuclein interacting protein, SNCAIP) is a 919 amino acid protein that associates with α synuclein and promotes the formation of cytosolic inclusions in neuronal cells. The synuclein family members, including α-synuclein and β-synuclein, are predominantly expressed in the brain, where they influence synaptic regulation and neuronal plasticity. Synphilin-1 contains modular protein domains, such as ankyrin-like repeats and a coiled-coil domain.While both α-synuclein and synphilin-1 are coexpressed in Lewy bodies of patients with Parkinson’s disease, only mutations in the gene for α-synuclein have been determined to confer pathogenicity.

Specificity:

Synphilin-1 (R846) polyclonal antibody detects endogenous levels of Synphilin-1 protein.

Alternative names:

Synphilin-1; Sph1; Alpha-synuclein-interacting protein; SNCAIP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 815-867 of Human Synphilin-1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 100 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com