Background:

Prostaglandin E synthase (PGE synthase), also known as PIG12 and MGST1-L1, is a member of protein super family MAPEG, which consists of membrane associated proteins involved in eicosanoid and glutathione metabolism. The expression of this membrane-associated protein can be induced by the pro-inflammatory cytokine, IL-1β. PGE synthase is expressed in seminal vesicles, deferent ducts, kidney, heart and spleen. The enzyme activity of PGE synthase in most organs is glutathione-dependent. PGE synthase may play a significant role in the progression of Alzheimer’s disease.

Specificity:

PGE synthase (I79) polyclonal antibody detects endogenous levels of PGE synthase protein.

Alternative names:

Prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; Short name=MGST1-L1; Microsomal prostaglandin E synthase 1; Short name=MPGES-1; p53-induced gene 12 protein; PTGES; MGST1L1; MPGES1; PGES; PIG12

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 51-100 of Human PGE synthase.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~17 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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