Background:

Protein names: Nuclear export mediator factor NEMF; Serologically defined colon cancer antigen 1; Gene names: NEMF; SDCCAG1. Function: Plays a role in nuclear export. Subunit structure: Interacts (via its N-terminus) with XPO1. Subcellular location: Nucleus.Tissue specificity: Expressed in brain, heart, liver, lung, spleen, and skeletal muscle. Also expressed at lower levels in stomach and testis. Domain: The N-terminal domain contains a nuclear export signal. The C-terminal domain may interact with cargo proteins. Miscellaneous: Active in normal lung tissue, but is inactive in several lung cancer cell lines.

Specificity:

NY-CO-1 (K914) polyclonal antibody detects endogenous levels of NY-CO-1 protein.

Alternative names:

Nuclear export mediator factor NEMF; Antigen NY-CO-1; Serologically defined colon cancer antigen 1; NEMF; SDCCAG1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 881-930 of Human NY-CO-1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 110 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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