Background:

The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-7 is a member of the atypical type II cadherin family that lacks the HAV cell recognition sequence found in type I cadherins. Although the absence of an HAV sequence decreases cell adhesion specificity, cadherin-7 contributes to cell organization by mediating homophilic cell adhesion in the brain, testis and prostate.

Specificity:

Cadherin-7 (R678) polyclonal antibody detects endogenous levels of Cadherin-7 protein.

Alternative names:

Cadherin-7; CDH7; CDH7L1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 645-693 of Human Cadherin-7.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 87 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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