Background:

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF191 (Zinc finger protein 191), also known as ZNF24, KOX17, ZSCAN3 or RSG-A, is a 368 amino acid nuclear protein that belongs to the Krueppel C2H2-type zinc-finger protein family. Expressed in tissues throughout the body with the exception of heart, ZNF191 functions as a transcriptional repressor for a variety of proteins, such as VEGF (vascular endothelial growth factor), and is thought to be important for early embryonic development and cell proliferation. ZNF191 contains four C2H2-type zinc fingers and one SCAN box domain and, upon DNA damage, may be phosphorylated by ATM or ATR.

Specificity:

KOX17 (K22) polyclonal antibody detects endogenous levels of KOX17 protein.

Alternative names:

KOX17; Retinoic acid suppression protein A; RSG A; RSGA; Zfp191; Zinc finger and SCAN domain containing protein 3; Zinc finger protein 191; Zinc finger protein 24; Zinc finger protein KOX17; ZNF 24; ZNF191; ZSCAN 3; ZSCAN3;

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to the N-terminus of Human KOX17.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 42 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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