Background:

Vascular endothelial cell growth inhibitor (VEGI also known as TNFRSF15 or TL1), a member of the TNF superfamily, has a signaling pathway similar to TNF and is most likely a multifunctional cytokine. VEGI is found in brain, reproductive, and late developmental stage embryonic tissues and expressed predominantly in endothelial cells. VEGI is an angiogenesis inhibitor of the TNF family and functions in part by directly inhibiting endothelial cell proliferation.VEGI may act as an autocrine factor to induce apoptosis in endothelial cells via activation of multiple signaling pathways, including stress protein kinases as well as certain caspases

Specificity:

VEGI (F141) polyclonal antibody detects endogenous levels of VEGI protein.

Alternative names:

Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor; TNFSF15; TL1; VEGI

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 111-160 of Human VEGI.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 25 kDa

Applications:

IHC IF

Usage:

IHC: 1:50~1:200 IF: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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