Background:

The humanized monoclonal anti-PD1 antibody can effectively block the combination between PDL1 and PD1, and will not cause HAMA reaction (anti mouse antibody response). Programmed cell death protein 1 (PD-1) (UniProt Q15116), is a type I single transmembrane protein encoded by the PDCD1 gene in human. T-cell activation is generally self-limited as activated T cells express receptors such as PD-1. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 can bind two different but related ligands, PDL-1 and PDL-2.PD-1 receptor and its ligands PD-L1 and PD-L2play a vital role in the induction and maintenance of peripheral tolerance. The humanized monoclonal anti-PD1 antibody has demonstrated durable antitumor activity.

Specificity:

PD1 monoclonal antibody (Humanized) detects endogenous levels of human PD1 protein. Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

Alternative names:

Programmed cell death protein 1; Protein PD-1; hPD-1; CD279; PDCD1; PD1

Species reactivity:

Human

Host:

Human

Ig type:

1mg/ml in PBS with 50% Glycerol.

Immunogen:

Variable region genes (including VH &VL) of this antibody were derived from a single B cell by PCR.

Purification & Purity:

Recombinant IgG antibodies were expressed and secreted by 293F cells and purified by Protein A.

Molecular weight:

~ 32 kDa

Applications:

Neutralization/Block

Usage:

Neutralization/Block

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com