Background:

Substance P (also designated NK-1) is an active peptide, known as a Tachykinin, that affects diverse functions, including blood pressure regulation, peristalsis of the gut, salivation and the modulation of cellular immunity. Frag-ments of Substance P have differential binding capacities for Substance P receptors and have varying biological activities. For example, two amino- terminal fragments of Substance P are able to evoke an increase in GABA release. NK-1 receptor (NK-1R), also designated Substance P receptor, binds to Tachykinin peptides, including Substance P, Substance K and Neuromedin K. In response to Substance P binding, NK-1R signals IL-12 production.

Specificity:

Substance P polyclonal antibody reacts specifically with Substance P. No crossreactivity with related tachykinins (Neurokinin A, Neurokinin B, and Kassinin).

Alternative names:

Protachykinin-1; PPT; TAC1; SP

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to mature of Substance P of human origin.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Molecular weight:

~ 15 kDa

Applications:

IHC IF

Usage:

IHC: 1:100~1:500 IF: 1:100~1:500

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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