Background:

IFT88 (Intraflagellar transport protein 88), also known as TG737 or TTC10 (TPR repeat protein 10), is an 833 amino acid protein that contains 12 TPR repeats and belongs to the TPR family. Expressed in lung, heart, liver, brain, pancreas, kidney and skeletal muscle, IFT88 is thought to interact with other intraflagellar transport proteins and may play a role in the assembly and maintenance of the vertebrate outer segment. Additionally, IFT88 is thought to function as a centrosomal protein that may regulate the G1 to S phase cell cycle transition in non-ciliated cells. Defects in the gene encoding IFT88 may be associated with the pathogenesis of polycystic kidney disease, a genetic disorder that is characterized by the presence of cysts within the kidneys. IFT88 expression is downregulated in hepatocellular carcinomas, suggesting a role for IFT88 in tumor suppression. Multiple isoforms of IFT88 exist due to alternative splicing events.

Specificity:

IFT88 polyclonal antibody detects endogenous levels of IFT88 protein.

Alternative names:

Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10; TG737; TTC10

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human IFT88.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 94 kDa

Applications:

IHC

Usage:

IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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