Background:

PDRG (p53 and DNA damage regulated), also known as PDRG1 or C20orf126, is a 133 amino acid protein that localizes to the cytoplasm and belongs to the prefoldin subunit beta family. Expressed predominately in normal testicular tissue, PDRG is functionally induced by ultraviolet light and is thought to play a role in chaperone-mediated protein folding, possibly playing a role in cellular degradation. The gene encoding PDRG maps to human chromosome 20, which houses over 600 genes some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.

Specificity:

PDRG1 polyclonal antibody detects endogenous levels of PDRG1 protein.

Alternative names:

p53 and DNA damage-regulated protein 1; PDRG1; C20orf126, PDRG

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant fragment corresponding to a region within amino acids 1-133 of Human PDRG1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 16 kDa

Applications:

IHC

Usage:

IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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