Background:

GGPS1 (geranylgeranyl diphosphate synthase 1), also known as GGPPS, GGPPSase (geranylgeranyl pyrophosphate synthetase) or GGPPS1, is a member of the FPP/GGPP synthetase family of trans-prenyltransferases. Predominantly expressed in testis, heart and skeletal muscle, GGPS1 localizes to the cytoplasm and catalyzes the formation of geranylgeranyl pyrophosphate (GGPP), a precursor of geranylgeranylated proteins and carotenoids. GGPP is a major isoprenoid responsible for the C20-prenylation of proteins and the regulation of the nuclear hormone receptor LXRå. More specifically, GGPS1 functions as an oligomeric molecule and mediates the condensation of farnesyl diphosphate (FPP) with isopentenyl diphosphate to yield GGPP. GGPS1 contains five amino acid motifs that are conserved in trans-prenyltransferases and three potential N-glycosylation sites.

Specificity:

GGPS1 polyclonal antibody detects endogenous levels of GGPS1 protein.

Alternative names:

Geranylgeranyl pyrophosphate synthase; GGPP synthase; GGPPSase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase; GGPS1

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant fragment corresponding to a region within amino acids 1-295 of Human GGPS1.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 35 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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