Background:

Phosphoinositide 3-kinase activity is implicated in assorted cellular responses activated by mammalian cell surface receptors and the regulation of protein sorting in yeast. The p110γ (PIK3CG) enzyme is activated in vitro by both the α and βγ subunits of heterotrimeric GTP-binding proteins (G proteins) and does not associate with a p85 adaptor molecule. PI 3-kinase C2γ, also designated p110γ, may link signaling through G protein-coupled receptors to the generation of phosphoinositide second messengers that are phosphorylated in the D-3 position. The PI 3-kinase C2γ gene encodes a 1,050 amino acid polypeptide with 36% identity to human PI 3-kinase C2α. Research indicates that PI 3-kinase C2γ can block the growth of human colon cancer cells.

Specificity:

PIK3C2G polyclonal antibody detects endogenous levels of PIK3C2G protein.

Alternative names:

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; PI3K-C2-gamma; Short name=PtdIns-3-kinase C2 subunit gamma; Phosphoinositide 3-kinase-C2-gamma; PI 3-kinase C2γ; PI3KC2γ

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

A synthetic peptide corresponding to residues in Human PIK3C2G.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 171 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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