Background:

CD160, also known as NK1, BY55 or NK28, is a 181 amino acid lipid-anchored cell membrane glycoprotein that contains one immunoglobulin-like domain. Expressed in small intestine, spleen and functional NK (natural killer) and T cytotoxic lymphocytes, CD160 exists as a disulfide-linked homomultimer that functions as a receptor for MHC (major histocompatability complex) molecules and is thought to regulate the function of NK cells. Additionally, CD160 interacts with HVEM (herpesvirus entry mediator) and, via this interaction, is able to negatively regulate CD4+ T cell activation, indicating a role in immune system regulation. Multiple isoforms of CD160 exist due to alternative splicing events. The gene encoding CD160 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.

Specificity:

CD160 (T45) polyclonal antibody detects endogenous levels of CD160 protein.

Alternative names:

CD160 antigen; Natural killer cell receptor BY55; CD160; CD160; BY55

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 21-70 of Human CD160.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 19 kDa

Applications:

WB

Usage:

WB: 1:500~1:1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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