Background:

PMPCA (peptidase (mitochondrial processing) alpha), also known as alpha-MPP, P-55, INPP5E or MPPA, is a 525 amino acid protein that belongs to the peptidase M16 family and exists as a heterodimer of alpha and beta subunits. Localizing to mitochondrial matrix, PMPCA cleaves transit peptides from mitochondrial protein precursors. PMPCA is encoded by a gene that maps to human chromosome 9 , which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.

Specificity:

PMPCA polyclonal antibody detects endogenous levels of PMPCA protein.

Alternative names:

INPP5E; KIAA0123; MPPA; Alpha-MPP; P-55; α-MPP; MPP-α; MPPα;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein of human PMPCA.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 110 kDa

Applications:

WB

Usage:

WB 1:500 - 1:2000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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